The chromosomal distribution of CpG islands in the mouse: Evidence for genome scrambling in the rodent lineage

被引：36

作者：

Cross, SH ^{[1
]}

Lee, M ^{[1
]}

Clark, VH ^{[1
]}

Craig, JM ^{[1
]}

Bird, AP ^{[1
]}

Bickmore, WA ^{[1
]}

机构：

[1] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

来源：

GENOMICS | 1997年 / 40卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1006/geno.1996.4598

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have prepared a library of mouse whole CPG islands using a methyl-CpG binding domain column. The distribution of CpG islands in the mouse genome was determined by FISH, using the library as a probe. Unlike in other vertebrate genomes that have been examined (human and chicken), extreme clustering of CpG islands was not seen in the mouse genome. No individual murine chromosome stood out as being either very gene-rich or very gene-poor. Despite the more even distribution of CpG islands in the mouse at a gross chromosomal level, at finer resolution concentrations of CpG; islands are seen to correspond to the R-band early replicating regions of the genome. (C) 1997 Academic Press.

引用

页码：454 / 461

页数：8

共 25 条

[1] NUMBER OF CPG ISLANDS AND GENES IN HUMAN AND MOUSE [J].

ANTEQUERA, F ;

BIRD, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11995-11999

[2]

Bond D, 1983, OXFORD MONOGRAPHS ME, P198

[3] DIFFERENTIAL DISTRIBUTION OF LONG AND SHORT INTERSPERSED ELEMENT SEQUENCES IN THE MOUSE GENOME - CHROMOSOME KARYOTYPING BY FLUORESCENCE INSITU HYBRIDIZATION [J].

BOYLE, AL ;

BALLARD, SG ;

WARD, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7757-7761

[4] THE DISTRIBUTION OF CPG ISLANDS IN MAMMALIAN CHROMOSOMES [J].

CRAIG, JM ;

BICKMORE, WA .

NATURE GENETICS, 1994, 7 (03) :376-382

[5] PURIFICATION OF CPG ISLANDS USING A METHYLATED DNA-BINDING COLUMN [J].

CROSS, SH ;

CHARLTON, JA ;

NAN, XS ;

BIRD, AP .

NATURE GENETICS, 1994, 6 (03) :236-244

[6]

Imoto H, 1994, DNA Res, V1, P239, DOI 10.1093/dnares/1.5.239

[7] HUMAN GENOME ORGANIZATION - ALU, LINES, AND THE MOLECULAR-STRUCTURE OF METAPHASE CHROMOSOME BANDS [J].

KORENBERG, JR ;

RYKOWSKI, MC .

CELL, 1988, 53 (03) :391-400

[8]

Lyon, 1996, GENETIC VARIANTS STR

[9]

Lyon M. F., 1995, Mouse Genome, V93, P23

[10]

MARSHALLGRAVES JA, 1994, HUMAN GENE MAPPING 1, P962

← 1 2 3 →