Plasma cell leukemia 3 months after autologous blood cell transplantation for multiple myeloma

被引:2
作者
Koskela, K
Pelliniemi, TT
Lakkala, T
Remes, K
机构
[1] Univ Turku, Cent Hosp, Dept Med, FIN-20520 Turku, Finland
[2] Univ Turku, Cent Hosp, Dept Hematol Lab, FIN-20520 Turku, Finland
[3] Univ Turku, Cent Hosp, Dept Med Genet, FIN-20520 Turku, Finland
[4] MediCity Res Ctr, Turku, Finland
关键词
multiple myeloma; intensive therapy; autologous stem cell transplantation; autologous blood cell transplantation; karyotypic analysis;
D O I
10.1038/sj.bmt.1701080
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
We describe a patient with multiple myeloma who was treated with intensive therapy and autologous blood cell transplantation as her first-line treatment, The disease relapsed 3 months after the transplant as plasma cell leukemia and the patient succumbed in 4 weeks, We suggest that an aggressive plasma cell clone may be selected during the course of intensive treatment, Complex karyotypic findings are also presented.
引用
收藏
页码:305 / 307
页数:3
相关论文
共 10 条
[1]   A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma [J].
Attal, M ;
Harousseau, JL ;
Stoppa, AM ;
Sotto, JJ ;
Fuzibet, JG ;
Rossi, JF ;
Casassus, P ;
Maisonneuve, H ;
Facon, T ;
Ifrah, N ;
Payen, C ;
Bataille, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (02) :91-97
[2]   PROGNOSTIC FACTORS IN AUTOLOGOUS STEM-CELL TRANSPLANTATION FOR MULTIPLE-MYELOMA - AN EBMT REGISTRY STUDY [J].
BJORKSTRAND, B ;
GOLDSTONE, AH ;
LJUNGMAN, P ;
BRANDT, L ;
BRUNET, S ;
CARLSON, K ;
PRENTICE, HG ;
CAVO, M ;
SAMSON, D ;
DELAURENZI, A ;
VERDONCK, LF ;
PROCTOR, S ;
FERRANT, A ;
SIERRA, J ;
AUZANNEAU, G ;
TROUSSARD, X ;
GRAVETT, P ;
REMES, K ;
GAHRTON, G .
LEUKEMIA & LYMPHOMA, 1994, 15 (3-4) :265-272
[3]   Allogeneic bone marrow transplantation versus autologous stem cell transplantation in multiple myeloma: A retrospective case-matched study from the European group for blood and marrow transplantation [J].
Bjorkstrand, B ;
Ljungman, P ;
Svensson, H ;
Hermans, J ;
Alegre, A ;
Apperley, J ;
Blade, J ;
Carlson, K ;
Cavo, M ;
Ferrant, A ;
Goldstone, AH ;
deLaurenzi, A ;
Majolino, I ;
Marcus, R ;
Prentice, HG ;
Remes, K ;
Samson, D ;
Sureda, A ;
Verdonck, LF ;
Volin, L ;
Gahrton, G .
BLOOD, 1996, 88 (12) :4711-4718
[4]   Allogeneic bone marrow transplantation in multiple myeloma [J].
Gahrton, G .
BRITISH JOURNAL OF HAEMATOLOGY, 1996, 92 (02) :251-254
[5]  
KLEIN B, 1995, SEMIN HEMATOL, V32, P4
[6]  
KOSMO MA, 1987, SEMIN HEMATOL, V24, P202
[7]  
MARIETTE X, 1994, BONE MARROW TRANSPL, V14, P47
[8]   TRANSPLANTATION OF CD34(+) PERIPHERAL-BLOOD PROGENITOR CELLS AFTER HIGH-DOSE CHEMOTHERAPY FOR PATIENTS WITH ADVANCED MULTIPLE-MYELOMA [J].
SCHILLER, G ;
VESCIO, R ;
FREYTES, C ;
SPITZER, G ;
SAHEBI, F ;
LEE, M ;
WU, CH ;
CAO, J ;
LEE, JC ;
HONG, CH ;
LICHTENSTEIN, A ;
LILL, M ;
HALL, J ;
BERENSON, R ;
BERENSON, J .
BLOOD, 1995, 86 (01) :390-397
[9]  
TRICOT G, 1995, BONE MARROW TRANSPL, V16, P7
[10]  
Zandecki M, 1996, BRIT J HAEMATOL, V94, P217