Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK11195

被引：213

作者：

Pappata, S

Levasseur, M

Gunn, RN

Myers, R

Crouzel, C

Syrota, A

Jones, T

Kreutzberg, GW

Banati, RB

机构：

[1] CEA, Serv Hosp Frederic Joliot, INSERM U334, Direct Sci Vivant, F-91401 Orsay, France

[2] Hop Orsay, Serv Neurol, Orsay, France

[3] Hammersmith Hosp, Med Res Ctr, Cyclotron Unit, London, England

[4] Max Planck Inst Neurobiol, Dept Neuromorphol, Martinsried, Germany

来源：

NEUROLOGY | 2000年 / 55卷 / 07期

关键词：

D O I：

10.1212/WNL.55.7.1052

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using quantitative PET, the authors studied the binding of [C-11]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [C-11]PK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in [C-11]PK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.

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页码：1052 / 1054

页数：3

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