5-HT2 modulation of AY-9944 induced atypical absence seizures

被引:14
作者
Bercovici, Eduard
Cortez, Miguel A.
Snead, O. Carter, III
机构
[1] Hosp Sick Children, Div Neurol, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[3] Univ Toronto, Brain & Behav Program, Div Neurol, Dept Pediat,Fac Med, Toronto, ON, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
absence seizures; AY-9944; EEG; serotonin; DOI; mCPP;
D O I
10.1016/j.neulet.2007.02.062
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigated the role of 5-HT2A and 5-HT2C receptors in atypical absence seizures (AAS) induced by trans-1,4-bis[2-chloro-benzylaminomethyl] cyclohexane, dihydrocholoride (AY-9944). The total duration and number and mean duration of the spontaneous bursts of slow spike-and-wave discharges (SSWD) that characterize the AY model were measured using electrocorticographic (ECoG) recordings in freely moving animals. In a randomized counterbalanced dose response design, rats were treated with either the 5-HT2A agonist 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI, 0.5, 1 or 2 mg/kg), the 5-HT2C preferring agonist m-chlorophenylpiperazine (mCPP, 1, 2, or 4 mg/kg), the 5-HT2A antagonist ketanserin (2.5 or 5 mg/kg), or vehicle. DOI significantly reduced the total duration and number of SSWD. In contrast, mCPP had no effect on total duration or number of SSWD. Ketanserin exacerbated the number of SSWD at 2.5 mg/kg but produced mixed results at 5.0 mg/kg. However, none of the treatments affected the mean SSWD duration. These data support the hypothesis that 5HT(2A) receptors are involved in the pathology of experimental atypical absence seizures. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:13 / 17
页数:5
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