EXAFS analyses of technetium(I) carbonyl complexes -: stability studies in solutions

被引：9

作者：

Seifert, S

Künstler, JU

Gupta, A

Funke, H

Reich, T

Hennig, C

Rossberg, A

Pietzsch, HJ

Alberto, R

Johannsen, B ^{[1
]}

机构：

[1] Res Ctr Rossendorf, Inst Bioinorgan & Radiopharmaceut Chem, D-01314 Dresden, Germany

[2] Res Ctr Rossendorf, Inst Radiochem, D-01314 Dresden, Germany

[3] Univ Zurich, Inst Inorgan Chem, CH-8057 Zurich, Switzerland

来源：

RADIOCHIMICA ACTA | 2000年 / 88卷 / 3-4期

关键词：

Tc-99/99m; Re; carbonyl complexes; EXAFS; stability studies;

D O I：

10.1524/ract.2000.88.3-4.239

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

EXAFS analyses were successfully used to determine the structure of Re and Tc carbonyl thioether complexes in solid and liquid samples. In connection with chromatographic and mass spectrometric methods the behaviour of Tc carbonyl dithioether complexes in aqueous solution was studied. It was found that complexes containing a bidentate thioether ligand are able to react with water by exchange of the chloride ion, which results in the formation of a cationic complex. As expected, the exchange proceeds faster at the n.c.a. level because of concentration differences.

引用

收藏

页码：239 / 245

页数：7

相关论文

共 22 条

[1] CONFORMATIONAL STUDIES OF TRANSITION-METAL CARBONYL-COMPLEXES OF 1,5-DITHIACYCLOOCTANE (1,5-DTCO) AND CRYSTAL-STRUCTURE OF [RECL(CO)(3),(1,5-DTCO)] [J].

ABEL, EW ;

ORRELL, KG ;

POOLE, MC ;

SIK, V ;

HURSTHOUSE, MB ;

MAZID, MA .

POLYHEDRON, 1995, 14 (05) :585-597

[2] THE SYNTHESIS AND DYNAMIC BEHAVIOR OF HALOGENTRICARBONYLRHENIUM(I) COMPLEXES OF SOME STERICALLY HINDERED DITHIOETHERS [J].

ABEL, EW ;

CORBEN, R ;

MOSS, I ;

ORRELL, KG ;

RICHARDSON, NR ;

SIK, V .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1988, 344 (03) :343-350

[3] Application of technetium and rhenium carbonyl chemistry to nuclear medicine. Preparation of [NEt4](2)[TcCl3(CO)(3)] from [NBu4][TcO4] and structure of [NEt4][Tc-2(mu-Cl)(3)(CO)(6)]; structures of the model complexes [NEt4][Re-2(mu-OEt)(2)(mu-OAc)(CO)(6)] and [ReBr({-CH2S(CH2)(2)Cl}(2))(CO)(3)] [J].

Alberto, R ;

Schibli, R ;

Angst, D ;

Schubiger, PA ;

Abram, U ;

Abram, S ;

Kaden, TA .

TRANSITION METAL CHEMISTRY, 1997, 22 (06) :597-601

[4]

Alberto R, 1996, TOP CURR CHEM, V176, P149

[5] METAL-CARBONYL SYNTHESES .22. LOW-PRESSURE CARBONYLATION OF [MOCL(4)](-) AND [MO4](-) - THE TECHNETIUM(I) AND RHENIUM(I) COMPLEXES [NET(4)](2)[MCL(3)(CO)(3)] [J].

ALBERTO, R ;

SCHIBLI, R ;

EGLI, A ;

SCHUBIGER, PA ;

HERRMANN, WA ;

ARTUS, G ;

ABRAM, U ;

KADEN, TA .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1995, 493 (1-2) :119-127

[6] A novel organometallic aqua complex of technetium for the labeling of biomolecules:: Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in aqueous solution and its reaction with a bifunctional ligand [J].

Alberto, R ;

Schibli, R ;

Egli, A ;

Schubiger, AP ;

Abram, U ;

Kaden, TA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (31) :7987-7988

[7] First application of fac-[99mTc(OH2)3(CO)3]+ in bioorganometallic chemistry:: Design, structure, and in vitro affinity of a 5-HT1A receptor ligand labeled with 99mTc [J].

Alberto, R ;

Schibli, R ;

Schubiger, AP ;

Abram, U ;

Pietzsch, HJ ;

Johannsen, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (25) :6076-6077

[8]

ALBERTO R, 1999, TECHNETIUM RHENIUM O, P27

[9] SYNCHROTRON X-RAY STUDIES OF METAL-BASED DRUGS AND METABOLITES [J].

ELDER, RC ;

EIDSNESS, MK .

CHEMICAL REVIEWS, 1987, 87 (05) :1027-1046

[10]

George G., 1995, EXAFSPAK: A suite of computer programs for analysis of X-ray absorption spectra