Dexamethasone modulates IL-13 and IL-10 expression

被引：2

作者：

Cannarile, L ^{[1
]}

Venditti, G ^{[1
]}

Ayroldi, E ^{[1
]}

Delfino, DV ^{[1
]}

Migliorati, G ^{[1
]}

机构：

[1] Univ Perugia, Pharmacol Sect, Dept Clin Med Pathol & Pharmacol, Sch Med, I-06122 Perugia, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 1997年 / 10卷 / 03期

关键词：

DEX; IL-10; IL-13; T lymphocytes;

D O I：

10.1177/039463209701000302

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL-)-10 and IL,-13 are Th2-cell-associated cytokines with a variety of biologic activities in immune and inflammatory responses, It is known that glucocorticoids (GCs) modulate inflammatory and immune functions, In fact, GCs are involved to regulate the transcription of cytokines which are relevant in chronic inflammation and cell-mediated immune response, In the present study we analyzed, in vitro, the effects of DEX on the expression of the IL-10 and IL-13 lymphokines in murine spleen and thymus cells, DEX-stimulation induced down-regulation of the expression of IL-10 and IL,-13 mRNA, This effect was already evident 0.5 hr after treatment and persisted in time, in both resting and activated lymphocytes. These results suggest that GCs could have inhibitory effect on Th2 cytokine production.

引用

页码：175 / 182

页数：8

共 46 条

[1] IMMUNOSUPPRESSION BY GLUCOCORTICOIDS - INHIBITION OF NF-KAPPA-B ACTIVITY THROUGH INDUCTION OF I-KAPPA-B SYNTHESIS [J].

AUPHAN, N ;

DIDONATO, JA ;

ROSETTE, C ;

HELMBERG, A ;

KARIN, M .

SCIENCE, 1995, 270 (5234) :286-290

[2] ANTIINFLAMMATORY ACTIONS OF STEROIDS - MOLECULAR MECHANISMS [J].

BARNES, PJ ;

ADCOCK, I .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (12) :436-441

[3] GENE-REGULATION BY STEROID-HORMONES [J].

BEATO, M .

CELL, 1989, 56 (03) :335-344

[4]

BODGAN C, 1991, J EXP MED, V174, P1549

[5]

BROSKI AP, 1994, TRANSPLANTATION, V57, P4

[6]

BROWN KD, 1989, J IMMUNOL, V142, P679

[7]

BYRON KA, 1992, IMMUNOLOGY, V77, P624

[8] 2 TYPES OF MOUSE HELPER T-CELL CLONE .3. FURTHER DIFFERENCES IN LYMPHOKINE SYNTHESIS BETWEEN TH1 AND TH2 CLONES REVEALED BY RNA HYBRIDIZATION, FUNCTIONALLY MONOSPECIFIC BIOASSAYS, AND MONOCLONAL-ANTIBODIES [J].

CHERWINSKI, HM ;

SCHUMACHER, JH ;

BROWN, KD ;

MOSMANN, TR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (05) :1229-1244

[9]

COHEN JJ, 1984, J IMMUNOL, V132, P38

[10] REGULATION OF MURINE LYMPHOKINE PRODUCTION INVIVO .3. THE LYMPHOID-TISSUE MICROENVIRONMENT EXERTS REGULATORY INFLUENCES OVER T-HELPER CELL-FUNCTION [J].

DAYNES, RA ;

ARANEO, BA ;

DOWELL, TA ;

HUANG, K ;

DUDLEY, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) :979-996

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