Prospects for the use of NK cells in immunotherapy of human cancer

被引：438

作者：

Ljunggren, Hans-Gustaf ^{[1
]}

Malmberg, Karl-Johan ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, S-14186 Huddinge, Sweden

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 05期

关键词：

D O I：

10.1038/nri2073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Current insights into the molecular specificities that regulate natural killer (NK)-cell function suggest that it might be possible to design NK-cell-based immunotherapeutic strategies against human cancer. Here, we describe evidence for NK-cell targeting of human tumours and address crucial questions that, in our opinion, require consideration for the development of successful NK-cell-based therapies. Appropriately used, we predict that NK cells will have a role, both directly and in combination with other treatment modalities, in future treatment of cancer.

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页码：329 / 339

页数：11

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