Arenaviruses other than Lassa virus

被引:138
作者
Charrel, RN [1 ]
de Lamballerie, X [1 ]
机构
[1] Fac Med, Unite Virus Emergents, IFR 48, IRD,UR 034,EA 3292, F-13005 Marseille, France
关键词
Arenavirus; bioterrorism; viral hemorrhagic fever; Lassa virus; Guanarito virus; Machupo virus; Junin virus; Sabia virus; ribavirin;
D O I
10.1016/S0166-3542(02)00202-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The family Arenaviridae includes 23 viral species, of which 5 can cause viral hemorrhagic fevers with a case fatality rate of about 20%. These five viruses are Junin, Machupo, Guanarito, Sabia and Lassa virus, the manipulation of which requires biosafety level 4 facilities. They are included in the Category A Pathogen List established by the Center for Disease Control and Prevention that groups agents with the greatest potential for adverse public health impact and mass casualties whether a situation characterized by a ill-intentioned abuse of natural or engineered arenavirus would be encountered. The aims of this article are to (i) summarize the current situation; (ii) provide information to help anticipating the effects to be expected in such a situation; and to (iii) emphasize the need for fundamental research to allow the development of diagnostic, prevention and therapeutic tools as countermeasures to weaponized arenaviruses. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:89 / 100
页数:12
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