Support for the involvement of TPH2 gene in affective disorders

被引：90

作者：

Harvey, M

Shink, E

Tremblay, M

Gagné, B

Raymond, C

Labbé, M

Walther, DJ

Bader, M

Barden, N ^{[1
]}

机构：

[1] CHUL, Res Ctr, Ste Foy, PQ, Canada

[2] Max Planck Inst Mol Genet, Dept Ropers Human Genet, Neurochem Grp, Berlin, Germany

[3] Mouse Lab, Berlin, Germany

[4] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

MOLECULAR PSYCHIATRY | 2004年 / 9卷 / 11期

关键词：

D O I：

10.1038/sj.mp.4001557

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Disturbance of the serotonergic system has been suggested as a factor in the pathogenesis of affective disorders. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the serotonin biosynthetic pathway, and a new TPH isoform, TPH2, has been identified in the brain and localized to the long arm of chromosome 12 in a region that has been reported to contain bipolar and major depressive disorder susceptibility genes. An SNP-based association study on a case/control sample gave support to the existence of an affective disorder-associated haplotype in the TPH2 gene.

引用

页码：980 / 981

页数：2

共 10 条

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