Reduced Kv1.3 potassium channel expression in human prostate cancer

被引:51
作者
Abdul, Mansoor [1 ]
Hoosein, Naseema [1 ]
机构
[1] Claflin Univ, Dept Biol, Orangeburg, SC 29115 USA
关键词
prostate; cancer; potassium channel; Kv1.3; grade; stage;
D O I
10.1007/s00232-006-0065-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The presence of Kv1.3 voltage-gated potassium channels in rat and human prostate epithelial cells has been previously reported. We examined, by immunohistochemistry, Kv1.3 levels in 10 normal human prostate, 18 benign prostatic hyperplasia (BPH) and 147 primary human prostate cancer (Pca) specimens. We found high epithelial expression of Kv1.3 in all normal prostate, 16 BPH and 77 (52%) Pca specimens. Compared to normal, Kv1.3 levels were reduced in 1 (6%) BPH specimen and in 70 (48%) Pca specimens. We found a signifficant inverse correlation between Kv1.3 levels and tumor grade (r =) -0.25, P = 0.003) as well as tumor stage (r =) -0.27, P = 0.001). Study of an additional 30 primary Pca specimens showed that 15 (50%) had reduced Kv1.3 immunostaining compared to matched normal prostate tissue. Our data suggest that in Pca reduced Kv1.3 expression occurs frequently and may be associated with a poor outcome.
引用
收藏
页码:99 / 102
页数:4
相关论文
共 15 条
[1]  
Abdul M, 2003, ANTICANCER RES, V23, P3347
[2]  
Abdul M, 2002, ONCOL REP, V9, P961
[3]   Expression and activity of potassium ion channels in human prostate cancer [J].
Abdul, M ;
Hoosein, N .
CANCER LETTERS, 2002, 186 (01) :99-105
[4]   Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: A possible role in T cell proliferation [J].
Conforti, L ;
Petrovic, M ;
Mohammad, D ;
Lee, S ;
Ma, Q ;
Barone, S ;
Filipovich, AH .
JOURNAL OF IMMUNOLOGY, 2003, 170 (02) :695-702
[5]  
Defarias FP, 1995, RECEPTOR CHANNEL, V3, P273
[6]   Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines:: electrophysiological, pharmacological and molecular characterisation [J].
Fraser, SP ;
Grimes, JA ;
Diss, JKJ ;
Stewart, D ;
Dolly, JO ;
Djamgoz, MBA .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2003, 446 (05) :559-571
[7]   The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia [J].
Grunnet, M ;
Rasmussen, HB ;
Hay-Schmidt, A ;
Klaerke, DA .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1616 (01) :85-94
[8]   Ion channels and cancer [J].
Kunzelmann K. .
The Journal of Membrane Biology, 2005, 205 (3) :159-173
[9]   Potassium channels in rat prostate epithelial cells [J].
Ouadid-Ahidouch, H ;
Van Coppenolle, F ;
Le Bourhis, X ;
Belhaj, A ;
Prevarskaya, N .
FEBS LETTERS, 1999, 459 (01) :15-21
[10]  
Panyi G, 2005, EUR BIOPHYS J BIOPHY, V34, P515