APOE genotype is a risk factor for neuropathy severity in diabetic patients

被引：24

作者：

Bedlack, RS

Edelman, D

Gibbs, JW

Kelling, D

Strittmatter, W

Saunders, AM

Morgenlander, J

机构：

[1] Duke Univ, Med Ctr, Div Neurol, Durham, NC 27705 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27705 USA

[3] Durham Vet Affairs Med Ctr, Durham, NC USA

[4] NE Med Ctr, Dept Med, Concord, NC USA

[5] GlaxoSmithKline, Genet Res, Raleigh, NC USA

来源：

NEUROLOGY | 2003年 / 60卷 / 06期

关键词：

D O I：

10.1212/01.WNL.0000056689.50682.94

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This cross-sectional study tested the hypothesis that APOE genotype is a risk factor for diabetic neuropathy severity. A model with age, duration of diabetes, and APOE genotype was found to predict (p = 0.0083) severity on the Neuropathy Impairment Score in the Lower Limbs (NISLL). Considering genotype alone, patients with APOE 3/4 and 4/4 genotypes had 3 more NISLL points than patients with other genotypes. This impact on severity is equivalent to having 15 extra years of age or diabetes duration.

引用

页码：1022 / 1024

页数：3

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