MgtC: a key player in intramacrophage survival

被引:68
作者
Alix, Eric
Blanc-Potard, Anne-Beatric
机构
[1] INSERM, Espri, F-30908 Nimes 02, France
[2] Univ Montpellier I, UFR Med, F-30908 Nimes 02, France
关键词
D O I
10.1016/j.tim.2007.03.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several bacterial pathogens have evolved strategies to survive in macrophages and create a replicative niche within phagosomes. The bacterial factor MgtC is a key player in intramacrophage survival, being important for virulence in diverse intracellular pathogens. MgtC is also required for growth under magnesium limitation. Recent studies provide new clues on the role of MgtC in macrophages, which seems to be unlinked to adaptation to a low Mg2+ microenvironment. In addition, we discuss the unexpected finding that MgtC modulates host P-type ATPase activity.
引用
收藏
页码:252 / 256
页数:5
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