Studies of the cellular distribution of superoxide dismutases in adult and fetal rat tissues

被引：9

作者：

Mackler, B ^{[1
]}

Person, RE ^{[1
]}

Nguyen, TD ^{[1
]}

Fantel, AG ^{[1
]}

机构：

[1] Univ Washington, Birth Defects Res Lab, Dept Pediat, Div Congenital Defects, Seattle, WA 98195 USA

来源：

FREE RADICAL RESEARCH | 1998年 / 28卷 / 02期

关键词：

superoxide dismutase; ETP; cytoplasm; fetal tissues;

D O I：

10.3109/10715769809065798

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activities of three types of superoxide dismutase in tissue fractions were significantly lower in fetal and adult brain and fetal limb preparations than in fetal and adult heart preparations. An exception was the cytoplasmic fraction of adult brain that had levels of Cu, Zn-superoxide dismutase activity comparable to those in cyto-plasmic fractions of heart. In addition, Mn superoxide dismutase activity appeared to be very low in all fetal mitochondrial matrix fractions and cyto-plasmic fractions as well as in adult brain. Finally, the results of these studies emphasize the importance of two antioxidant defense systems in the tissues studied, one associated with the mitochondrial electron transport system and the other, the cytosolic Cu, Zn enzyme.

引用

页码：125 / 129

页数：5

共 7 条

[1] SPECTRA AND REACTION KINETICS OF RESPIRATORY PIGMENTS OF HOMOGENIZED AND INTACT CELLS [J].