Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

被引：45

作者：

Hsiue, Ging-Ho ^{[1
]}

Lo, Chun-Liang

Cheng, Ching-Hao

Lin, Che-Ping

Huang, Chun-Kai

Chen, Hung-Hao

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 300, Taiwan

[2] Natl Tsing Hua Univ, Dept Appl Chem, Hsinchu 300, Taiwan

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2007年 / 45卷 / 04期

关键词：

atom transfer radical polymerization (ATRP); diblock copolymers; nanoparticles; poly(D; L-lactide) (PLA); poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC);

D O I：

10.1002/pola.21741

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by H-1 NMR, atomic force microscopy, and xi-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)block-poly(D,L-lactide). (c) 2006 Wiley Periodicals, Inc.

引用

页码：688 / 698

页数：11

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