The tumor suppressor protein p16INK4a

被引：269

作者：

Serrano, M ^{[1
]}

机构：

[1] CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

EXPERIMENTAL CELL RESEARCH | 1997年 / 237卷 / 01期

关键词：

D O I：

10.1006/excr.1997.3824

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor suppressor protein p16(INK4a) (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16(INK4a) gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16(INK4a) is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16(INK4a) are starting to be characterized. (C) 1997 Academic Press.

引用

页码：7 / 13

页数：7

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