Dietary sialic acid supplementation improves learning and memory in piglets

被引:223
作者
Wang, Bing
Yu, Bing
Karim, Muhsin
Hu, Honghua
Sun, Yun
McGreevy, Paul
Petocz, Peter
Held, Suzanne
Brand-Miller, Jennie
机构
[1] Univ Sydney, Human Nutr Unit, Sch Mol & Microbial Biosci, Sydney, NSW 2006, Australia
[2] Univ Sydney, Royal Prince Alfred Hosp, Dept Mol & Clin Genet, Sydney, NSW 2006, Australia
[3] Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia
[4] Macquarie Univ, Dept Stat, Sydney, NSW 2109, Australia
[5] Univ Bristol, Ctr Behav Biol, Dept Clin Vet Sci, Bristol, Avon, England
关键词
sialic acid supplementation; learning and memory; gene expression; brain development; piglets;
D O I
10.1093/ajcn/85.2.561
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Sialic acid, a key component of both human milk oligosaccharides and neural tissues, may be a conditional nutrient during periods of rapid brain growth. Objective: We tested the hypothesis that variations in the sialic acid content of a formula milk would influence early learning behavior and gene expression of enzymes involved in sialic acid metabolism in piglets. Design: Piglets (n = 54) were allocated to 1 of 4 groups fed sow milk replacer supplemented with increasing amounts of sialic acid as casein glycomacropeptide for 35 d. Learning performance and memory were assessed with the use of easy and difficult visual cues in an 8-arm radial maze. Brain ganglioside and sialoprotein concentrations and mRNA expression of 2 learning-associated genes (ST8SIA4 and GNE) were measured. Results: In both tests, the supplemented groups learned in significantly fewer trials than did the control group, with a dose-response relation for the difficult task (P = 0.018) but not the easy task. In the hippocampus, significant dose-response relations were observed between amount of sialic acid supplementation and mRNA levels of ST8SIA4 (P = 0.002) and GNE (P = 0.004), corresponding with proportionate increases in protein-bound sialic acid concentrations in the frontal cortex. Conclusions: Feeding a protein-bound source of sialic acid during early development enhanced learning and increased expression of 2 genes associated with learning in developing piglets. Sialic acid in mammalian milks could play a role in cognitive development.
引用
收藏
页码:561 / 569
页数:9
相关论文
共 30 条
  • [1] Task difficulty and the specificity of perceptual learning
    Ahissar, M
    Hochstein, S
    [J]. NATURE, 1997, 387 (6631) : 401 - 406
  • [2] Anderson JW, 1999, AM J CLIN NUTR, V70, P525
  • [3] The intracellular concentration of sialic acid regulates the polysialylation of the neural cell adhesion molecule
    Bork, K
    Reutter, W
    Gerardy-Schahn, R
    Horstkorte, R
    [J]. FEBS LETTERS, 2005, 579 (22) : 5079 - 5083
  • [4] Botting N, 1998, DEV MED CHILD NEUROL, V40, P652
  • [5] Attention deficit hyperactivity disorders and other psychiatric outcomes in very low birthweight children at 12 years
    Botting, N
    Powls, A
    Cooke, RWI
    Marlow, N
    [J]. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 1997, 38 (08) : 931 - 941
  • [6] New perspectives on nutrition enhance outcomes for premature infants
    Brumberg, H
    La Gamma, EF
    [J]. PEDIATRIC ANNALS, 2003, 32 (09): : 617 - 625
  • [8] ORAL AND INTRAPERITONEAL ADMINISTRATION OF N-ACETYLNEURAMINIC ACID - EFFECT ON RAT CEREBRAL AND CEREBELLAR N-ACETYLNEURAMINIC ACID
    CARLSON, SE
    HOUSE, SG
    [J]. JOURNAL OF NUTRITION, 1986, 116 (05) : 881 - 886
  • [9] INACTIVATION OF THE N-CAM GENE IN MICE RESULTS IN SIZE-REDUCTION OF THE OLFACTORY-BULB AND DEFICITS IN SPATIAL-LEARNING
    CREMER, H
    LANGE, R
    CHRISTOPH, A
    PLOMANN, M
    VOPPER, G
    ROES, J
    BROWN, R
    BALDWIN, S
    KRAEMER, P
    SCHEFF, S
    BARTHELS, D
    RAJEWSKY, K
    WILLE, W
    [J]. NATURE, 1994, 367 (6462) : 455 - 459
  • [10] Consolidation of memory for odour-reward association requires transient polysialylation of the neural cell adhesion molecule in the rat hippocampal dentate gyrus
    Foley, AG
    Hedigan, K
    Roullet, P
    Moricard, Y
    Murphy, KJ
    Sara, SJ
    Regan, CM
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 74 (04) : 570 - 576