Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma

被引:24
作者
Gupta, Rakesh K. [1 ]
Haris, Mohammad
Husain, Nuzhat
Husain, Mazhar
Prasad, Kashi N.
Pauliah, Mohan
Srivastava, Chhitiz
Tripathi, Mukesh
Rastogi, Manu
Behari, Sanjay
Singh, Anup
Rathore, Divya
Rathore, Ram Kishore S.
机构
[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Radiodiag, Lucknow 226014, Uttar Pradesh, India
[2] King Georges Med Univ, Dept Pathol, Lucknow, Uttar Pradesh, India
[3] King Georges Med Univ, Dept Neurosurg, Lucknow, Uttar Pradesh, India
[4] Sanjay Gandhi Postgrad Inst Med Sci, Dept Microbiol, Lucknow, Uttar Pradesh, India
[5] Sanjay Gandhi Postgrad Inst Med Sci, Dept Anaesthesiol, Lucknow, Uttar Pradesh, India
[6] Sanjay Gandhi Postgrad Inst Med Sci, Dept Neurosurg, Lucknow, Uttar Pradesh, India
[7] Indian Inst Technol, Dept Math, Kanpur 208016, Uttar Pradesh, India
关键词
tuberculoma; brain; perfusion MRI; angiogenesis; vascular endothelial growth factor; microvascular density;
D O I
10.1097/01.rct.0000243443.10739.16
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: The aim of this study was to correlate the perfusion indices with magnetic resonance imaging-derived cellular and necrotic fraction of the tuberculoma and angiogenesis metrics on histopathology. Methods: We performed dynamic contrast-enhanced magnetic resonance imaging in 13 excised brain tuberculoma patients. Microvascular density and vascular endothelial growth factor (VEGF)-expressing cells were quantified from the excised tuberculoma. The cellular and necrotic fractions of the tuberculomas were quantified on a postcontrast T1-weighted imaging. Results: Relative cerebral blood volume of cellular portion significantly correlated with cellular fraction volume (r = 0.882, P < 0.001), microvascular density (r = 0.900, P < 0.001), and VEGF (r = 0.886, P < 0.001) of the 13 excised tuberculomas. Microvascular density also correlated significantly with VEGF (r = 0.919, P < 0.001). Conclusions: Relative cerebral blood volume is a measure of angiogenesis in the cellular fraction of the brain tuberculoma. This infort-nation may be of value in predicting the therapeutic response in future.
引用
收藏
页码:335 / 341
页数:7
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