Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition-Pictet-Spengler sequence

被引：81

作者：

Wu, Xiaoyu ^{[1
]}

Dai, Xiaoyang ^{[1
]}

Nie, Linlin ^{[1
]}

Fang, Huihui ^{[1
]}

Chen, Jie ^{[1
]}

Ren, Zhongjiao ^{[1
]}

Cao, Weiguo ^{[1
]}

Zhao, Gang ^{[2
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Key Lab Synthet Chem Nat Subst, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 16期

基金：

中国国家自然科学基金;

关键词：

IMINIUM ION CYCLIZATION; INDOLE-DERIVATIVES; ASYMMETRIC-SYNTHESIS; ALKALOIDS; (+)-GEISSOSCHIZINE; (-)-GEISSOSCHIZOL; LACTAMS;

D O I：

10.1039/c001512a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective three-component Michael addition-Pictet-Spengler sequence of beta-ketoesters 1, alpha,beta-unsaturated aldehydes 2 and tryptamines 4 represents a facile and rapid one-pot access to highly substituted indoloquinolizidines in moderate to excellent yields and good to excellent enantioselectivities.

引用

页码：2733 / 2735

页数：3

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