The Los Alamos hepatitis C sequence database

被引：310

作者：

Kuiken, C ^{[1
]}

Yusim, K ^{[1
]}

Boykin, L ^{[1
]}

Richardson, R ^{[1
]}

机构：

[1] Los Alamos Natl Lab, HCV Database, Los Alamos, NM 87544 USA

来源：

BIOINFORMATICS | 2005年 / 21卷 / 03期

关键词：

D O I：

10.1093/bioinformatics/bth485

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: The hepatitis C virus (HCV) is a significant threat to public health worldwide. The virus is highly variable and evolves rapidly, making it an elusive target for the immune system and for vaccine and drug design. At present, some 30 000 HCV sequences have been published. A central website that provides annotated sequences and analysis tools will be helpful to HCV scientists worldwide. Results: The HCV sequence database collects and annotates sequence data and provides them to the public via a website that contains a user-friendly search interface and a large number of sequence analysis tools, based on the model of the highly regarded Los Alamos HIV database. The HCV sequence database was officially launched in September 2003. Since then, its usage has steadily increased and is now at an average of similar to280 visits per day from distinct IP addresses.

引用

页码：379 / 384

页数：6

共 21 条

[1] THE NATURAL-HISTORY OF COMMUNITY-ACQUIRED HEPATITIS-C IN THE UNITED-STATES
ALTER, MJ
MARGOLIS, HS
KRAWCZYNSKI, K
JUDSON, FN
MARES, A
ALEXANDER, WJ
HU, PY
MILLER, JK
GERBER, MA
SAMPLINER, RE
MEEKS, EL
BEACH, MJ
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (27) : 1899 - 1905
[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, SF
Madden, TL
Schaffer, AA
Zhang, JH
Zhang, Z
Miller, W
Lipman, DJ
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (17) : 3389 - 3402
[3] Centers for Disease Control and Prevention (CDC), 2003, MMWR Morb Mortal Wkly Rep, V52, P901
[4] ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME
CHOO, QL
KUO, G
WEINER, AJ
OVERBY, LR
BRADLEY, DW
HOUGHTON, M
[J]. SCIENCE, 1989, 244 (4902) : 359 - 362
[5] Farci P, 2000, SEMIN LIVER DIS, V20, P103
[6] FELSENSTEIN J, 1984, PHYLIP PHYLOGENY INF
[7] Chronic hepatitis C in African Americans and other minority groups
Fleckenstein J.
[J]. Current Gastroenterology Reports, 2004, 6 (1) : 66 - 70
[8] AIDS - Diversity considerations in HIV-1 vaccine selection
Gaschen, B
Taylor, J
Yusim, K
Foley, B
Gao, F
Lang, D
Novitsky, V
Haynes, B
Hahn, BH
Bhattacharya, T
Korber, B
[J]. SCIENCE, 2002, 296 (5577) : 2354 - 2360
[9] Retrieval and on-the-fly alignment of sequence fragments from the HIV database
Gaschen, B
Kuiken, C
Korber, B
Foley, B
[J]. BIOINFORMATICS, 2001, 17 (05) : 415 - 418
[10] Bad time for bonzo? Experimental models of hepatitis C virus infection, replication, and pathogenesis
Grakoui, A
Hanson, HL
Rice, CM
[J]. HEPATOLOGY, 2001, 33 (03) : 489 - 495

← 1 2 3 →