In vivo Plasmodium falciparum sensitivity to chloroquine in humans (Ivory Coast).

被引：2

作者：

Adou-Bryn, KD ^{[1
]}

Memain, SD ^{[1
]}

Ouhon, J ^{[1
]}

Assoumou, A ^{[1
]}

Kone, M ^{[1
]}

机构：

[1] Fac Med, Lab Parasitol Mycol, Abidjan 01, Cote Ivoire

来源：

MEDECINE ET MALADIES INFECTIEUSES | 1999年 / 29卷 / 07期

关键词：

chloroquine; Ivory Coast; P. falciparum malaria;

D O I：

10.1016/S0399-077X(99)80086-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives - A study of in vivo Plasmodium falciparum sensitivity to chloroquine was carried out in 102 patients from eight months to 15 years of age, between May and July 1994 in humans (West Ivory Coast). Materials and methods - This study was included in the national P. falciparum-sensitivity supervision program. Chloroquine was administered in accordance with the standard seven day WHO protocol i.e. administered dose of 25 mg/kg, in split doses, over three days. Results - Of 102 treated patients, 13 apyretic patients (12. 75%) harbored RII-RIII type chloroquine-resistant strains with the exception of a patient who became febrile on D7. Conclusion - Considering these results, the authors suggest that the first-line treatment with chloroquine be continued for uncomplicated malaria in humans. (C) 1999 Elsevier Paris.

引用

页码：476 / 479

页数：4

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