Intramolecular radical cyclization of 2-haloethanal allyl acetal and allyl 2-halophenyl ether with a Grignard reagent in the presence of iron(II) chloride

被引：49

作者：

Hayashi, Y ^{[1
]}

Shinokubo, H ^{[1
]}

Oshima, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Sakyo Ku, Kyoto 60601, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 1-2期

关键词：

D O I：

10.1016/S0040-4039(97)10489-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 2-iodoethanal alkenyl acetals, generated by iodoetherization from butyl vinyl ether and allylic alcohols, with phenylmagnesium bromide in the presence of a catalytic amount of FeCl2 provided tetrahydrofuran derivatives in good yields. Allyl 2-halophenyl ethers also afforded dihydrobenzofuran derivatives upon treatment with phenylmagnesium bromide under FeCl2 catalysis. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：63 / 66

页数：4

共 14 条

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