Soluble L-selectin levels in serum and cerebrospinal fluid in patients with multiple sclerosis and systemic lupus erythematosus

被引：16

作者：

Baraczka, K

Pozsonyi, T

Nékám, K

Virányi, M

Seszták, M

Szongoth, M

Jakab, L

机构：

[1] Natl Inst Rheumat Physiother, Dept Neuroimmunol, H-1525 Budapest, Hungary

[2] III Clin Internal Med, Dept Neuroimmunol, Budapest, Hungary

[3] III Clin Internal Med, Semmelweis Med Sch, Budapest, Hungary

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2000年 / 102卷 / 02期

关键词：

multiple sclerosis; systemic lupus erythematosus; cerebrospinal fluid; soluble L-selectin;

D O I：

10.1034/j.1600-0404.2000.102002114.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Soluble L-selectin (sL-selectin) concentrations were measured in paired samples of serum and cerebrospinal fluid by an ELISA method. Patients with several forms of multiple sclerosis (MS) and systemic lupus erythematosus with central nervous system involvement (SLE-CNS) were investigated. Elevated CSF sl-selectin concentrations were found in patients with SLE-CNS (7.62+/-3.31 ng/ml) and with relapsing-remitting form of MS (6.99 +/- 4.72 ng/ml) compared to the control group (4.00 +/- 0.95 ng/ml). The data presented suggest some similarities between inflammatory/immunological events in the central nervous system in patients with SLE-CNS and relapsing-remitting form of MS. Immunological heterogeneity in MS is suspected.

引用

页码：114 / 117

页数：4

共 17 条

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[2] Increases in soluble VCAM-1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon beta-1b [J].