Increased fat due to estrogen deficiency induces bone loss by elevating monocyte chemoattractant protein-1 (MCP-1) production

被引：26

作者：

Kim, Youn-Young ^{[1
,2
]}

Kim, Song-Hee ^{[1
,2
]}

Oh, Sora ^{[1
,2
]}

Sul, Ok-Joo ^{[1
,2
]}

Lee, Hye-Young ^{[1
,2
]}

Kim, Hyun-Ju ^{[3
]}

Kim, Shin-Yoon ^{[3
]}

Choi, Hye-Seon ^{[1
,2
]}

机构：

[1] Univ Ulsan, Dept Biol Sci, Brain Korea Program 21, Ulsan 680749, South Korea

[2] Univ Ulsan, Immunomodulat Res Ctr, Ulsan 680749, South Korea

[3] Kyungpook Natl Univ, Sch Med, Skeletal Dis Genome Res Ctr, Taegu 700412, South Korea

来源：

MOLECULES AND CELLS | 2010年 / 29卷 / 03期

关键词：

KAPPA-B LIGAND; OSTEOCLAST DIFFERENTIATION; RECEPTOR ACTIVATOR; BODY-COMPOSITION; ADIPOSE-TISSUE; EXPRESSION; PATHOGENESIS; STIMULATION; THERAPY; DENSITY;

D O I：

10.1007/s10059-010-0027-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ovariectomy (OVX)-induced estrogen withdrawal resulted in both bone loss and an increase in fat. We observed elevated osteoclast (OC) formation by bone marrow-derived macrophages treated with medium conditioned by fats from OVX mice, but not from sham-operated mice. Fats from OVX mice expressed and secreted higher levels of monocyte chemoattractant protein-1 (MCP-1) than those from sham-operated mice. Increased fat resulting from estrogen deficiency is thus responsible for bone loss due to enhanced OC formation, which is, at least partly, a consequence of elevated MCP-1 production.

引用

页码：277 / 282

页数：6

共 42 条

[1]

Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone [J].