Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions

被引：73

作者：

Sato, T ^{[1
]}

Hashizume, M ^{[1
]}

Hotta, Y ^{[1
]}

Okahata, Y ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 268501, Japan

来源：

BIOMETALS | 1998年 / 11卷 / 02期

关键词：

aluminium ion; B16 melanoma cell; lanthanoid; morphology; proliferation;

D O I：

10.1023/A:1009273827598

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM. B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions. B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G(0)/G(1) to S state.

引用

页码：107 / 112

页数：6

共 31 条

[1]

ANGILHERI LJ, 1979, EUR J CANCER, V15, P1459

[2]

BOYD KS, 1976, EUR J CELL BIOL, V14, P91

[3]

MR IMAGING OF MENINGIOMAS INCLUDING STUDIES WITH AND WITHOUT GADOLINIUM-DTPA [J].