Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

被引：1012

作者：

Littman, Dan R. ^{[1
,2
]}

Rudensky, Alexander Y. ^{[3
,4
]}

机构：

[1] NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA

[2] NYU, Sch Med, Mol Pathogenesis Program, Kimmel Ctr Biol & Med,Skirball Inst, New York, NY 10016 USA

[3] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

来源：

CELL | 2010年 / 140卷 / 06期

关键词：

ROR-GAMMA-T; DE-NOVO DIFFERENTIATION; GROWTH-FACTOR-BETA; TGF-BETA; FOXP3; EXPRESSION; DENDRITIC CELLS; CUTTING EDGE; HELPER-CELLS; TARGET GENES; GRANZYME-B;

D O I：

10.1016/j.cell.2010.02.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of "self'' and provoking overexuberant inflammatory processes. In this Review we discuss this balance achieved in large part by interactions of different classes of T lymphocytes that have potent pro- or anti-inflammatory activity in the context of genetic and environmental factors, particularly the commensal microbiota.

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页码：845 / 858

页数：14

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