Chemokines and breast cancer: A gateway to revolutionary targeted cancer treatments?

被引：21

作者：

Dowsland, MH ^{[1
]}

Harvey, JR ^{[1
]}

Lennard, TWJ ^{[1
]}

Kirby, JA ^{[1
]}

Ali, S ^{[1
]}

机构：

[1] Newcastle Univ, Sch Med, Sch Surg & Reprod Sci, Appl Immunobiol Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

CURRENT MEDICINAL CHEMISTRY | 2003年 / 10卷 / 07期

关键词：

chemokine; chemokine receptor; glycosaminoglycan; heparin; breast cancer; cancer; metastasis; treatment; MONOCYTE CHEMOATTRACTANT PROTEIN-1; HEPARAN-SULFATE PROTEOGLYCANS; HUMAN ENDOTHELIAL-CELLS; TUMOR-GROWTH; PROSTATE-CANCER; CXC CHEMOKINES; MACROPHAGE INFILTRATION; T-LYMPHOCYTES; IN-VITRO; EXPRESSION;

D O I：

10.2174/0929867033457944

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is an example of a solid tumour which is well treated in the early 74 stages of disease by surgical excision, but once metastatic spread has occurred, medical therapies (chemotherapy and radiotherapy) are highly toxic, expensive and palliative. It is known that certain tumours exhibit specific patterns of metastasis, chemokines may provide a molecular answer to this mystery. Chemokines and their receptors play important roles in the various stages of tumour development and metastasis. Chemokines interact with their specific receptors as well as interacting with the glycosaminoglycan (GAG) component of proteoglycan. We discuss the basic metastatic process and the involvement of chemokines in breast cancer biology. Finally, we summarize potential therapeutic applications of chemokines and chemokine/glycosaminoglycan interactions including chemokine agonists, antagonists, anti-sense therapy, immunotherapy and soluble GAGs, as well as future perspectives in this field.

引用

页码：579 / 592

页数：14

共 116 条

[1] The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity [J].