Inflammation and Neurogenesis in Temporal Lobe Epilepsy

被引：42

作者：

Bernardino, L. ^{[2
]}

Ferreira, R. ^{[2
]}

Cristovao, A. J. ^{[1
]}

Sales, F. ^{[3
]}

Malva, J. O. ^{[2
]}

机构：

[1] Univ Coimbra, Fac Med, Dept Zool, P-3004504 Coimbra, Portugal

[2] Univ Coimbra, Fac Med, Inst Biochem, P-3004504 Coimbra, Portugal

[3] Univ Coimbra Hosp, Dept Neurol, EEG Unit, P-3000075 Coimbra, Portugal

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2005年 / 4卷 / 04期

关键词：

Epilepsy; seizures; inflammation; cytokines; chemokines; neuroprotection; neurodegeneration; neurogenesis;

D O I：

10.2174/1568007054546171

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the present review is to discuss the evidence supporting the hypothesis that inflammation and neurogenesis play an important role in temporal lobe epilepsy (TLE) and to examine whether possible strategies that involve the pharmacological manipulation of inflammation/neurogenesis can lead to the development of novel approaches for the treatment of epilepsy. Since it is not yet clear whether the neuron-glia response obtained in this pathology is a secondary effect of an aggressive inflammation or if it is somehow related to the cause of the epileptic condition, with the present review we guide the readers through the complex and ambiguous crosstalk between neuroimmunology and epilepsy.

引用

页码：349 / 360

页数：12

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