Energy landscapes and solved protein-folding problems

被引：145

作者：

Wolynes, PG

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Ctr Theoret Biol Phys, La Jolla, CA 92093 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2005年 / 363卷 / 1827期

关键词：

energy landscape theory; protein folding; funnel;

D O I：

10.1098/rsta.2004.1502

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Energy-landscape theory has led to much progress in protein folding kinetics, protein structure prediction and protein design. Funnel landscapes describe protein folding and binding and explain how protein topology determines kinetics. Landscape-optimized energy functions based on bioinformatic input have been used to correctly predict low-resolution protein structures and also to design novel proteins automatically.

引用

收藏

页码：453 / 464

页数：12

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