Comparative studies on schistosomulicidal activity of mouse and rat eosinophils

被引：3

作者：

Mahakunkijcharoen, Y

Osada, Y

Nara, T

Horie, T

Takatsu, K

Kojima, S

机构：

[1] UNIV TOKYO, INST MED SCI, DEPT PARASITOL, MINATO KU, TOKYO 108, JAPAN

[2] UNIV TOKYO, INST MED SCI, DEPT IMMUNOL, TOKYO 108, JAPAN

[3] JUNTENDO UNIV, DEPT PARASITOL, TOKYO, JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1997年 / 114卷

关键词：

eosinophil; IL; 5; schistosomula; Schistosoma japonicum; killing activity; Fc receptors; adhesion;

D O I：

10.1159/000237716

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophils from interleukin (IL)-5 transgenic mice were shown to have antibody-dependent killing activity against the larvae of Schistosoma japonicum. However, in comparison with rat eosinophils, the schistosomulicidal activity of mouse eosinophils was lower. Flow cytometric analysis of the cells binding to mouse immunoglobulins demonstrated that rat cells were superior to mouse cells in the binding of mouse IgG. However, the adherence and schistosomulicidal activity of mouse cells were inhibited by rat anti-mouse Fc gamma receptor monoclonal antibody. These results suggest that the mechanism of killing by mouse eosinophils is mediated by IgG antibodies.

引用

页码：40 / 44

页数：5

共 23 条

[1] EOSINOPHILS AS MEDIATORS OF ANTIBODY-DEPENDENT DAMAGE TO SCHISTOSOMULA [J].