Biology of interleukin-22

被引：439

作者：

Wolk, Kerstin ^{[1
]}

Witte, Ellen ^{[1
]}

Witte, Katrin ^{[1
]}

Warszawska, Katarzyna ^{[1
]}

Sabat, Robert ^{[1
]}

机构：

[1] Univ Hosp Charite, Interdisciplinary Grp Mol Immunopathol Dermatol M, D-10117 Berlin, Germany

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2010年 / 32卷 / 01期

关键词：

Class II cytokine; IL-22BP; Antibacterial protein; Keratinocyte; Psoriasis; Autoimmune disease; II CYTOKINE RECEPTOR; PROINFLAMMATORY GENE-EXPRESSION; ENTERICA SEROVAR ENTERITIDIS; NITRIC-OXIDE-SYNTHASE; MUCOSAL HOST-DEFENSE; T-CELL; TH17; CELLS; INDUCIBLE FACTOR; CRYSTAL-STRUCTURE; BINDING-PROTEIN;

D O I：

10.1007/s00281-009-0188-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gamma delta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. Whereas in some aspects, IL-22 acts synergistically with tumor necrosis factor-alpha, IL-1 beta, or IL-17, most functions of IL-22 are unique. Importantly, IL-22 does not serve the communication between immune cells. It mainly acts on epithelial cells and hepatocytes, where it favors the antimicrobial defense, regeneration, and protection against damage and induces acute phase reactants and some chemokines. This chapter illuminates in detail the properties of IL-22 with respect to its gene, protein structure, cellular sources, receptors, target cells, biological effects, and, finally, its role in chronic inflammatory diseases, tumors, and infection.

引用

页码：17 / 31

页数：15

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