Protective effect of Japanese green tea extract on gnotobiotic mice infected with an Escherichia coli O157:H7 strain

被引：29

作者：

Isogai, E

Isogai, H

Takeshi, K

Nishikawa, T

机构：

[1] Sapporo Med Univ, Div Anim Experimentat, Sapporo, Hokkaido 0600061, Japan

[2] Hokkaido Inst Publ Hlth, Sapporo, Hokkaido 0600819, Japan

[3] Hokkaido Univ, Med Sci Lab, Sapporo, Hokkaido 0028074, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1998年 / 42卷 / 02期

关键词：

Escherichia coli O157; Japanese green tea; gnotobiotic mouse;

D O I：

10.1111/j.1348-0421.1998.tb02260.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the effect of Japanese green tea extract (JGTE) on enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection in a gnotobiotic mouse model, Gnotobiotic mice inoculated with an EHEC strain developed neurologic and systemic symptoms, usually culminating in death, In contrast, none of mice receiving dietary JGTE showed clinical signs or death, This report describes the effect of JGTE, which includes the inhibition of bacterial growth in vivo. The Shiga-like toxin (SLT) level in the feces of the JGTE diet group was significantly lower than that of the control group.

引用

页码：125 / 128

页数：4

共 14 条

[1] THE EPIDEMIOLOGY OF INFECTIONS CAUSED BY ESCHERICHIA-COLI O157-H7, OTHER ENTEROHEMORRHAGIC ESCHERICHIA-COLI, AND THE ASSOCIATED HEMOLYTIC UREMIC SYNDROME [J].