Impact of acellular mucin pools on survival in patients with complete pathological response to neoadjuvant treatment in rectal cancer

被引：25

作者：

Bhatti, Abu Bakar Hafeez ^{[1
]}

Akbar, Ali ^{[1
]}

Khattak, Shahid ^{[1
]}

Kazmi, Ather Saeed ^{[2
]}

Jamshed, Aarif ^{[3
]}

Syed, Aamir Ali ^{[1
]}

机构：

[1] Shaukat Khanum Mem Canc Hosp & Res Ctr, Dept Surg Oncol, Lahore, Pakistan

[2] Shaukat Khanum Mem Canc Hosp & Res Ctr, Dept Med Oncol, Lahore, Pakistan

[3] Shaukat Khanum Mem Canc Hosp & Res Ctr, Dept Radiat Oncol, Lahore, Pakistan

来源：

INTERNATIONAL JOURNAL OF SURGERY | 2014年 / 12卷 / 10期

关键词：

Rectal cancer; Mucin; Survival; PREOPERATIVE CHEMORADIOTHERAPY; CLINICAL-SIGNIFICANCE; CHEMORADIATION; RADIOTHERAPY; CARCINOMA;

D O I：

10.1016/j.ijsu.2014.07.267

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Rarely, patients with pathological complete response (PCR) after neoadjuvant chemoradiotherapy demonstrate acellular mucin pools. The prognostic significance of this finding is controversial. The objective of this study was to determine impact of acellular mucin pools on disease free and overall survival in patients with complete pathological response to neoadjuvant chemoradiotherapy in rectal cancer. Methods: One hundred and seventy two patients received neoadjuvant chemoradiotherapy for rectal cancer and underwent surgery. Patients were divided into two groups based on presence of acellular mucin pools. Locoregional failures, distant failures and deaths were compared. Expected 5 year disease free and overall survival was calculated. Results: Median follow-up was 36(4-94) months. Complete pathological response was identified in 35(20.3%) patients. Of these, 12(34.2%) had acellular mucin pools in resected specimen. Majority of mucin negative tumors were moderately differentiated (78% vs 25%) (P = 0.005). Median overall survival for mucin positive and mucin negative tumors was 4(1.3-5.7) and 3.3(0.1-6.3) years respectively. Expected 5 year disease free and overall survival for mucin positive and mucin negative tumors was 73% and 89% (P - 0.1) and 75% and 87% (P = 0.4). Conclusion: Acellular mucin pools in rectal cancer following a PCR to neoadjuvant treatment do not impact survival. (C) 2014 Published by Elsevier Ltd on behalf of Surgical Associates Ltd.

引用

页码：1123 / 1126

页数：4

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