Membrane microdomains and insulin resistance

被引：50

作者：

Inokuchi, Jin-ichi ^{[1
]}

机构：

[1] Tohoku Pharmaceut Univ, Div Glycopathol, Inst Mol Biomembranes & Glycobiol, Aoba Ku, Sendai, Miyagi 9818558, Japan

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

基金：

日本科学技术振兴机构;

关键词：

Ganglioside; GM3; Insulin resistance; Membrane microdomain (lipid raft); Insulin receptor; NECROSIS-FACTOR-ALPHA; GANGLIOSIDE GM3; TYROSINE PHOSPHORYLATION; PLASMA-MEMBRANE; ATHEROSCLEROTIC LESIONS; RECEPTOR SUBSTRATE-1; 3T3-L1; ADIPOCYTES; ADIPOSE-TISSUE; KINASE DOMAIN; CAVEOLAE;

D O I：

10.1016/j.febslet.2009.10.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new concept, that "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides", has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains and propose the new therapeutic strategy "membrane microdomain ortho-signaling therapy". (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1864 / 1871

页数：8

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