The HIV-TSG101 interface: recent advances in a budding field

被引：56

作者：

Freed, EO ^{[1
]}

机构：

[1] NIAID, Lab Mol Microbiol, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0966-842X(02)00013-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Efficient budding of HIV from the plasma membrane requires a small peptide motif, Pro-Thr/Ser-Ala-Pro (PTAP), located near the amino terminus of the p6 Gag protein. Studies from several laboratories have demonstrated that the ability of p6 to stimulate HIV budding requires a direct interaction between the PTAP motif and the host endosomal sorting protein TSG101. The structure of the PTAP-TSG101 binding site has recently been solved, providing valuable insights into this crucial protein-protein interaction.

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页码：56 / 59

页数：4

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