Antisense homology box-derived peptides represent a new class of endothelin receptor inhibitors

被引：21

作者：

Baranyi, L

Campbell, W

Ohshima, K

Fujimoto, S

Boros, M

Kaszaki, J

Okada, H

机构：

[1] Nagoya City Univ, Sch Med, Dept Mol Biol, Mizuho Ku, Nagoya, Aichi 467, Japan

[2] Fukushimura Hosp, Choju Med Inst, Toyohashi, Aichi 441, Japan

[3] Nagoya City Univ, Sch Med, Dept Pharmacol, Nagoya, Aichi 467, Japan

[4] Albert Szent Gyorgyi Med Univ, Inst Expt Surg, H-6723 Szeged, Hungary

来源：

PEPTIDES | 1998年 / 19卷 / 02期

关键词：

antagonist; complementary peptide; antisense homology box; endothelin receptor; hydropathic complementarity; inverse agonist;

D O I：

10.1016/S0196-9781(97)00370-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several peptides encoded by the sense and corresponding antisense DNA have been found to recognize and bind to each other. We developed software to search for sense-antisense regions within proteins taking into account the degeneracy of the genetic code, i.e., one amino acid can have several "antisense" counterparts. Using this approach, we searched endothelin receptor type A for intramolecular regions related in sense-antisense fashion. After locating these regions (termed "antisense homology boxes"), several corresponding peptides were synthesized. The four new ETA receptor fragment peptides ETR-P1 ("CALSVDRYRAVASW"), ETR-P3 ("QGIGPLITAIEI"), ETR-P4 ("IADNAERYSANLSSHV") and ETR-P6 ("LNRRNGSLRIALSEHLKNRREVA") reported here can inhibit ET-1 activity. (C) 1998 Elsevier Science Inc.

引用

页码：211 / 223

页数：13

共 35 条

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