Antielastin autoimmunity in tobacco smoking-induced emphysema

被引：434

作者：

Lee, Seung-Hyo

Goswami, Sangeeta

Grudo, Ariel

Song, Li-zhen

Bandi, Venkata

Goodnight-White, Sheila

Green, Linda

Hacken-Bitar, Joan

Huh, Joseph

Bakaeen, Faisal

Coxson, Harvey O.

Cogswell, Sebastian

Storness-Bliss, Claudine

Corry, David B.

Kheradmand, Farrah ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Med, Sect Pulm & Crit Care, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA

[3] Michael E DeBakey VA Med Ctr, Dept Pathol, Houston, TX 77030 USA

[4] Michael E DeBakey VA Med Ctr, Dept Radiol, Houston, TX 77030 USA

[5] Michael E DeBakey VA Med Ctr, Dept Surg, Houston, TX 77030 USA

[6] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA

[7] Vancouver Gen Hosp, Dept Radiol, Vancouver, BC V6Z 1Y6, Canada

来源：

NATURE MEDICINE | 2007年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nm1583

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

引用

收藏

页码：567 / 569

页数：3

相关论文

共 15 条

[1] Smoking and lung function of lung health study participants after 11 years [J].

Anthonisen, NR ;

Connett, JE ;

Murray, RP .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (05) :675-679

[2] Medical progress: Chronic obstructive pulmonary disease. [J].

Barnes, PJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (04) :269-280

[3] Chronic obstructive pulmonary disease - Inflammation of small airways and lung parenchyma [J].

Cosio, MG ;

Guerassimov, A .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (05) :S21-S25

[4] Quantitative computed tomography of chronic obstructive pulmonary disease [J].

Coxson, HO ;

Rogers, RM .

ACADEMIC RADIOLOGY, 2005, 12 (11) :1457-1463

[5] Mortality risk reduction associated with smoking cessation in patients with coronary heart disease - A systematic review [J].

Critchley, JA ;

Capewell, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (01) :86-97

[6] Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease [J].

DeMeo, DL ;

Celedón, JC ;

Lange, C ;

Reilly, JJ ;

Chapman, HA ;

Sylvia, JS ;

Speizer, FE ;

Weiss, ST ;

Silverman, EK .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 170 (12) :1294-1301

[7] An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema [J].

Grumelli, S ;

Corry, DB ;

Song, LZ ;

Song, L ;

Green, L ;

Huh, J ;

Hacken, J ;

Espada, R ;

Bag, R ;

Lewis, DE ;

Kheradmand, F .

PLOS MEDICINE, 2004, 1 (01) :75-83

[8] The nature of small-airway obstruction in chronic obstructive pulmonary disease [J].

Hogg, JC ;

Chu, F ;

Utokaparch, S ;

Woods, R ;

Elliott, WM ;

Buzatu, L ;

Cherniack, RM ;

Rogers, RM ;

Sciurba, FC ;

Coxson, HO ;

Paré, PD .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (26) :2645-2653

[9] Elastin fragments drive disease progression in a murine model of emphysema [J].

Houghton, AM ;

Quintero, PA ;

Perkins, DL ;

Kobayashi, DK ;

Kelley, DG ;

Marconcini, LA ;

Mecham, RP ;

Senior, RM ;

Shapiro, SD .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (03) :753-759

[10] Smoking related COPD and facial wrinkling: is there a common susceptibility? [J].

Patel, B. D. ;

Loo, W. J. ;

Tasker, A. D. ;

Screaton, N. J. ;

Burrows, N. P. ;

Silverman, E. K. ;

Lomas, D. A. .

THORAX, 2006, 61 (07) :568-571