Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: Lipid rafts mediate anti-allergic action of the catechin

被引:33
作者
Tachibana, H [1 ]
Fujimura, Y [1 ]
Yamada, K [1 ]
机构
[1] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Higashi Ku, Fukuoka 8128581, Japan
关键词
EGCG; lipid rafts; tea; cell membrane; binding; Fc epsilon RI; allergy;
D O I
10.1002/biof.552210174
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
High-affinity IgE receptor FcepsilonRI is key molecule in the IgE-mediated allergic reactions. Epigallocatechin-3-gallate (EGCG) has a suppressive effect of the expression of the FcepsilonRI. We show here that EGCG highly associates with plasma membrane microdomains, lipid rafts. The disruption of these lipid rafts caused a reduction of the amount of raft-associated EGCG and the FcepsilonRI-suppressive effect of EGCG. These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcepsilonRI expression.
引用
收藏
页码:383 / 385
页数:3
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