Salivary epidermal growth factor in oral cavity cancer

Salivary epidermal growth factor (EGF) effect on oral cancer biology is unknown. We examined changes in minute volumes of whole resting and stimulated saliva, EGF concentration and its output (ELISA) in whole resting and stimulated saliva before and 2 weeks after surgical treatment in oral carcinoma patients compared to the control group. After stimulation salivary flow increased both in the control (P = 0.003) and in the patients group-before (P = 0.007) and after surgery (P = 0.005). Higher stimulated saliva volume levels were observed before surgery than in post-treatment patients (P = 0.032). A trend was seen with increasing EGF salivary concentrations after tumour excision both in resting (P = 0.508) and stimulated (P = 0.647) saliva. A similar ascending tendency of EGF output in stimulated saliva of post-treatment patients was observed (P = 0.878). Decreased levels of EGF concentration in saliva before and its contrary tendency after surgical treatment may suggest an important role of EGF in oral cancer tumourogenesis. (C) 2004 Elsevier Ltd. All rights reserved.