Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

被引：21

作者：

Goodarzi, Mark O.

Antoine, Heath J.

Pall, Marita

Cui, Jinrui

Guo, Xiuqing

Azziz, Ricardo

机构：

[1] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA

[3] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA USA

来源：

FERTILITY AND STERILITY | 2007年 / 87卷 / 06期

关键词：

D O I：

10.1016/j.fertnstert.2006.11.041

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3 beta (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3 beta contributes to the pathophysiology and inherited basis of PCOS.

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收藏

页码：1473 / 1476

页数：4

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