MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis

被引：162

作者：

Alivernini, Stefano ^{[1
]}

Gremese, Elisa ^{[1
]}

McSharry, Charles ^{[2
]}

Tolusso, Barbara ^{[1
]}

Ferraccioli, Gianfranco ^{[1
]}

McInnes, Iain B. ^{[2
,3
]}

Kurowska-Stolarska, Mariola ^{[2
,3
]}

机构：

[1] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Inst Rheumatol, Rome, Italy

[2] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland

[3] Rheumatoid Arthrit Pathogenesis Ctr Excellence RA, Glasgow, Lanark, Scotland

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 8卷

关键词：

microRNA-155; inflammation; antibody production; arthritis rheumatoid; autoimmunity; REGULATORY T-CELLS; DOMAIN-CONTAINING INOSITOL-5-PHOSPHATASE; B-CELL; RHEUMATOID-ARTHRITIS; DENDRITIC CELLS; PERIPHERAL-BLOOD; SYNOVIAL-FLUID; IN-VIVO; INFLAMMATORY ARTHRITIS; MIR-155; CONTRIBUTES;

D O I：

10.3389/fimmu.2017.01932

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multi-functional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.

引用

页数：16

共 166 条

[1]

Synovial fluid macrophages are capable of osteoclast formation and resorption [J].

Adamopoulos, IE ;

Sabokbar, A ;

Wordsworth, BP ;

Carr, A ;

Ferguson, DJ ;

Athanasou, NA .

JOURNAL OF PATHOLOGY, 2006, 208 (01) :35-43

[2]

MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis [J].

Alivernini, Stefano ;

Kurowska-Stolarska, Mariola ;

Tolusso, Barbara ;

Benvenuto, Roberta ;

Elmesmari, Aziza ;

Canestri, Silvia ;

Petricca, Luca ;

Mangoni, Antonella ;

Fedele, Anna Laura ;

Di Mario, Clara ;

Gigante, Maria Rita ;

Gremese, Elisa ;

McInnes, Iain B. ;

Ferraccioli, Gianfranco .

NATURE COMMUNICATIONS, 2016, 7

[3]

The molecular hallmarks of epigenetic control [J].

Allis, C. David ;

Jenuwein, Thomas .

NATURE REVIEWS GENETICS, 2016, 17 (08) :487-500

[4]

Src homology 2 domain-containing inositol-5-phosphatase 1 (SITP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism [J].

An, HZ ;

Xu, HM ;

Zhang, MH ;

Zhou, J ;

Feng, T ;

Qian, C ;

Qi, RZ ;

Cao, XT .

BLOOD, 2005, 105 (12) :4685-4692

[5]

MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components [J].

Asirvatham, Ananthi J. ;

Gregorie, Christopher J. ;

Hu, Zihua ;

Magner, William J. ;

Tomasi, Thomas B. .

MOLECULAR IMMUNOLOGY, 2008, 45 (07) :1995-2006

[6]

Targeting cell migration in rheumatoid arthritis [J].

Asquith, Darren L. ;

Bryce, Steven A. ;

Nibbs, Robert J. B. .

CURRENT OPINION IN RHEUMATOLOGY, 2015, 27 (02) :204-211

[7]

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma [J].

Babar, Imran A. ;

Cheng, Christopher J. ;

Booth, Carmen J. ;

Liang, Xianping ;

Weidhaas, Joanne B. ;

Saltzman, W. Mark ;

Slack, Frank J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (26) :E1695-E1704

[8]

MicroRNAs: new regulators of immune cell development and function [J].

Baltimore, David ;

Boldin, Mark P. ;

O'Connell, Ryan M. ;

Rao, Dinesh S. ;

Taganov, Konstantin D. .

NATURE IMMUNOLOGY, 2008, 9 (08) :839-845

[9]

Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[10]

Micro-RNA-155 inhibits IFN-γ signaling in CD4+ T cells [J].

Banerjee, Arnob ;

Schambach, Felix ;

DeJong, Caitlin S. ;

Hammond, Scott M. ;

Reiner, Steven L. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (01) :225-231

← 1 2 3 4 5 6 7 8 9 10 →