学术探索
学术期刊
新闻热点
数据分析
智能评审

Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder

被引：65
作者：
Hemmings, SM
Kinnear, CJ
Niehaus, DJH
Moolman-Smook, JC
Lochner, C
Knowles, JA
Corfield, VA
Stein, DJ
机构：
[1] Univ Stellenbosch, MRC US, Ctr Mol & Cellular Biol, ZA-7505 Tygerberg, South Africa
[2] Univ Stellenbosch, MRC, Unit Anxiet Disorders, Dept Psychiat,Fac Hlth Sci, ZA-7505 Tygerberg, South Africa
[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
来源：
EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2003年 / 13卷 / 02期
基金：
英国医学研究理事会; 新加坡国家研究基金会;
关键词：
obsessive-compulsive disorder; genetics; association studies; Afrikaner;
D O I：
10.1016/S0924-977X(02)00129-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
There is increasing evidence that the aetiology of obsessive-compulsive disorder (OCD) has a marked genetic component, although the precise mechanism of inheritance is unclear. Clinical and pharmacological studies have implicated the serotonergic and dopaminergic systems in disease pathogenesis. This study investigated the role of attractive candidate genes in the serotonergic and dopaminergic pathways in the development of OCD. The distribution of selected polymorphic variants in the serotonin receptor type 2A and 1Dbeta (5-HT2A, 5-HT1Dbeta), dopamine transporter (DAT), dopamine receptor type 4 (DRD4) and monoamine-oxidase A (MAO-A) genes were analysed in 71 OCD cases and 129 control individuals in the genetically homogeneous Afrikaner population, by means of case-control association studies. Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation. (C) 2002 Elsevier Science B.V./ECNP All rights reserved.
引用
收藏
页码：93 / 98
页数：6
相关论文
共 57 条
[1]   Investigation of dopamine system genes in obsessive-compulsive disorder [J].
Billett, EA ;
Richter, MA ;
Sam, F ;
Swinson, RP ;
Dai, XY ;
King, N ;
Badri, F ;
Sasaki, T ;
Buchanan, JA ;
Kennedy, JL .
PSYCHIATRIC GENETICS, 1998, 8 (03) :163-169
[2]   Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder [J].
Camarena, B ;
Rinetti, G ;
Cruz, C ;
Gómez, A ;
de la Fuente, JR ;
Nicolini, H .
AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (03) :279-282
[3]   Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics [J].
Cruz, C ;
Camarena, B ;
King, N ;
Paez, F ;
Sidenberg, D ;
delaFuente, JR ;
Nicolini, H .
NEUROSCIENCE LETTERS, 1997, 231 (01) :1-4
[4]   Evidence of a long QT founder gene with varying phenotypic expression in South African families [J].
deJager, T ;
Corbett, CH ;
Badenhorst, CW ;
Brink, PA ;
Corfield, VA .
JOURNAL OF MEDICAL GENETICS, 1996, 33 (07) :567-573
[5]   DISEASE GENE-MAPPING IN ISOLATED HUMAN-POPULATIONS - THE EXAMPLE OF FINLAND [J].
DELACHAPELLE, A .
JOURNAL OF MEDICAL GENETICS, 1993, 30 (10) :857-865
[6]   Different roles for serotonin in anti-obsessional drug action and the pathophysiology of obsessive-compulsive disorder [J].
Delgado, PL ;
Moreno, FA .
BRITISH JOURNAL OF PSYCHIATRY, 1998, 173 :21-25
[7]   PUBLICATION BIAS IN CLINICAL RESEARCH [J].
EASTERBROOK, PJ ;
BERLIN, JA ;
GOPALAN, R ;
MATTHEWS, DR .
LANCET, 1991, 337 (8746) :867-872
[8]   ALTERATION OF SEROTONIN RELEASE IN THE GUINEA-PIG ORBITOFRONTAL CORTEX BY SELECTIVE SEROTONIN REUPTAKE INHIBITORS - RELEVANCE TO TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER [J].
ELMANSARI, M ;
BOUCHARD, C ;
BLIER, P .
NEUROPSYCHOPHARMACOLOGY, 1995, 13 (02) :117-127
[9]   5-HT2A promoter polymorphism-1438G/A, anorexia nervosa, and obsessive-compulsive disorder [J].
Enoch, MA ;
Kaye, WH ;
Rotondo, A ;
Greenberg, BD ;
Murphy, DL ;
Goldman, D .
LANCET, 1998, 351 (9118) :1785-1786
[10]   Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder [J].
Enoch, MA ;
Greenberg, BD ;
Murphy, DL ;
Goldman, D .
BIOLOGICAL PSYCHIATRY, 2001, 49 (04) :385-388
123456