共 51 条
Anatomical evidence for enteric neuroimmune interactions in Peyer's patches
被引:45
作者:

Vulchanova, Lucy
论文数: 0 引用数: 0
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机构: Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA

Casey, Melissa A.
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h-index: 0
机构: Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA

Crabb, Gwen W.
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h-index: 0
机构: Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA

Kennedy, William R.
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h-index: 0
机构: Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA

Brown, David R.
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h-index: 0
机构: Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA
机构:
[1] Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA
[2] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA
关键词:
enteric nervous system;
mucosal immunity;
substance P;
vasoactive intestinal peptide;
calcitonin gene-related peptide;
D O I:
10.1016/j.jneuroim.2007.01.014
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Peyer's patches (PP), a key component of the gut-associated lymphoid tissue, serve as the primary inductive sites for intestinal immunity. In the present study, we addressed the hypothesis that the morphological features of PP innervation are consistent with an immunomodulatory role for the enteric nervous system. Laser scanning confocal microscopy was used to collect images through large tissue volumes, yielding a three-dimensional perspective of the neuronal network superimposed on PP follicles from porcine jejunum and human ileum. Peptidergic nerve fibers were found in close apposition to immunocytes within PP subepithelial domes and the adjacent villi. The results suggest that nerve fibers in PP may participate in neuroimmune cross-talk within individual antigen-sampling sites as well as integrate information across multiple antigen-sampling sites. (c) 2007 Elsevier B.V. All rights reserved.
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页码:64 / 74
页数:11
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