One-pot, multicomponent route to pyrazoloquinolizinones

被引：83

作者：

Chebanov, Valentin A.

Saraev, Vyacheslav E.

Desenko, Sergey M.

Chemenko, Vitaliy N.

Shishkina, Svetlana V.

Shishkin, Oleg V.

Kobzar, Kiril M.

Kappe, C. Oliver

机构：

[1] Natl Acad Sci Ukraine, State Sci Inst, Inst Single Crystals, UA-61001 Kharkov, Ukraine

[2] Kral Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria

[3] Kral Franzens Univ Graz, CDLMC, A-8010 Graz, Austria

[4] Tech Univ Munich, D-85747 Garching, Germany

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 09期

关键词：

D O I：

10.1021/ol070411l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 5a-hydroxy-4,5,5a,6,7,8-hexahydropyrazolo[4,3-c]quinolizin-9-ones based on the three-component condensation of 5-aminopyrazoles, aromatic aldehydes, and cyclic 1,3-diketones is described. The multicomponent reaction is performed under strongly basic conditions applying controlled microwave heating in a sealed vessel and involves an unusual base-mediated ring-opening/recyclization of the cyclic 1,3-diketone moiety.

引用

页码：1691 / 1694

页数：4

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