Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir

被引：76

作者：

Held, TK

Biel, SS

Nitsche, A

Kurth, A

Chen, S

Gelderblom, HR

Siegert, W

机构：

[1] Klin Innere Med Schwerpunkt Hamatol & Onkol, D-13353 Berlin, Germany

[2] Robert Koch Inst, D-1000 Berlin, Germany

[3] Jinan Univ, Coll Med, Dept Internal Med, Guangzhou, Peoples R China

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 03期

关键词：

BK virus; hemorrhagic cystitis; cidofovir; CMV reactivation;

D O I：

10.1038/sj.bmt.1702487

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Hemorrhagic cystitis (HC) is a common complication following high-dose chemotherapy and bone marrow transplantation, and the treatment of virus-associated HC remains to be optimized. This is the first report on the successful use of cidofovir in a patient with HC and polyoma viruria concomitant with CMV reactivation after allogeneic BMT. Treatment led to a significant decrease in viruria and to sustained suppression of CMV reactivation. Administered with probenecid and hydration, cidofovir was well tolerated, and there were no side-effects.

引用

页码：347 / 350

页数：4

共 24 条

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