Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir

被引:76
作者
Held, TK
Biel, SS
Nitsche, A
Kurth, A
Chen, S
Gelderblom, HR
Siegert, W
机构
[1] Klin Innere Med Schwerpunkt Hamatol & Onkol, D-13353 Berlin, Germany
[2] Robert Koch Inst, D-1000 Berlin, Germany
[3] Jinan Univ, Coll Med, Dept Internal Med, Guangzhou, Peoples R China
关键词
BK virus; hemorrhagic cystitis; cidofovir; CMV reactivation;
D O I
10.1038/sj.bmt.1702487
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Hemorrhagic cystitis (HC) is a common complication following high-dose chemotherapy and bone marrow transplantation, and the treatment of virus-associated HC remains to be optimized. This is the first report on the successful use of cidofovir in a patient with HC and polyoma viruria concomitant with CMV reactivation after allogeneic BMT. Treatment led to a significant decrease in viruria and to sustained suppression of CMV reactivation. Administered with probenecid and hydration, cidofovir was well tolerated, and there were no side-effects.
引用
收藏
页码:347 / 350
页数:4
相关论文
共 24 条
[1]   Activities of various compounds against murine and primate polyomaviruses [J].
Andrei, G ;
Snoeck, R ;
Vandeputte, M ;
DeClercq, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :587-593
[2]   ASSOCIATION OF BK VIRURIA WITH HEMORRHAGIC CYSTITIS IN RECIPIENTS OF BONE-MARROW TRANSPLANTS [J].
ARTHUR, RR ;
SHAH, KV ;
BAUST, SJ ;
SANTOS, GW ;
SARAL, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (04) :230-234
[3]   ASSOCIATION OF BK VIRUS WITH FAILURE OF PROPHYLAXIS AGAINST HEMORRHAGIC CYSTITIS FOLLOWING BONE-MARROW TRANSPLANTATION [J].
BEDI, A ;
MILLER, CB ;
HANSON, JL ;
GOODMAN, S ;
AMBINDER, RF ;
CHARACHE, P ;
ARTHUR, RR ;
JONES, RJ .
JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (05) :1103-1109
[4]  
BIEL SS, 1999, CELL CULTURE PRACTIC, P111
[5]  
BIEL SS, 1999, ACTA MICROBIOL IMMUN, V46, P375
[6]  
Bogdanovic G, 1998, Pediatr Transplant, V2, P288
[7]  
Bogdanovic G, 1996, BONE MARROW TRANSPL, V17, P573
[8]   Treatment of adenovirus-associated haemorrhagic cystitis with ganciclovir [J].
Chen, FE ;
Liang, RHS ;
Lo, JY ;
Yuen, KY ;
Chan, TK ;
Peiris, M .
BONE MARROW TRANSPLANTATION, 1997, 20 (11) :997-999
[9]   High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine [J].
Childs, R ;
Sanchez, C ;
Engler, H ;
Preuss, J ;
Rosenfeld, S ;
Dunbar, C ;
van Rhee, F ;
Plante, M ;
Phang, S ;
Barrett, AJ .
BONE MARROW TRANSPLANTATION, 1998, 22 (09) :889-893
[10]  
DEVRIES CR, 1990, J UROLOGY, V143, P1