Current developments in the molecular genetics of the polycystic ovary syndrome

被引：13

作者：

Franks, S ^{[1
]}

Gharani, N

Waterworth, D

Batty, S

White, D

Williamson, R

McCarthy, M

机构：

[1] St Marys Hosp, Imperial Coll Sci Technol & Med, Sch Med, Dept Obstet & Gynaecol, London W2 1PG, England

[2] Imperial Coll Sci Technol & Med, Sch Med, Dept Biochem & Mol Genet, London, England

[3] Imperial Coll Sci Technol & Med, Sch Med, Metab Med Unit, London, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1998年 / 9卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1043-2760(98)00018-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic ovary syndrome (PCOS) is most likely a complex trait with an oligogenic basis. In this article, we present evidence from molecular genetic studies for involvement of the steroid synthesis gene CYP11a (coding for P450 cholesterol side-chain cleavage) in the aetiology of hyper-androgenism. Variation in the regulatory region of the insulin gene also appears to contribute to the development of PCOS.

引用

收藏

页码：51 / 54

页数：4

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