The epithelium takes centre stage in asthma and atopic dermatitis

被引：159

作者：

Holgate, Stephen T. ^{[1
]}

机构：

[1] Univ Southampton, Sch Med, Southampton SO16 6YD, Hants, England

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.it.2007.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Asthma and atopic dermatitis are epithelial disorders in which T helper 2 (Th2)-type inflammation has a prominent role. Thymic stromal lymphopoietin (TSLP) is a cytokine produced by the skin and airway epithelium that is capable of directing dendritic cells towards a Th2 response, thereby providing an essential link between epithelial cell activation and allergic-type inflammation. In addition, TSLP can interact directly with mast cells to initiate Th2 cytokine production to also provide a non-T cell route to mediate its pro-allergic effects. Induction of TSLP production occurs through the activation of epithelial Toll-like receptors to provide an important new link between innate immunity and allergic disease.

引用

页码：248 / 251

页数：4

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