Acaricidal daphnane diterpenoids from Trigonostemon reidioides (KURZ) CRAIB roots

被引：40

作者：

Soonthornchareonnon, N ^{[1
]}

Sakayarojkul, M

Isaka, M

Mahakittikun, V

Chuakul, W

Wongsinkongman, P

机构：

[1] Mahidol Univ, Fac Pharm, Dept Pharmacognosy, Bangkok 10400, Thailand

[2] Natl Ctr Genet Engn & Biotechnol, BIOTEC, Pathum Thani 12120, Thailand

[3] Mahidol Univ, Dept Parasitol, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand

[4] Mahidol Univ, Dept Pharmaceut Bot, Fac Pharm, Bangkok 10400, Thailand

[5] Minist Publ Hlth, Dept Med Sci, Bangkok 11000, Thailand

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 02期

关键词：

Trigonostemon redioides; acaricidal activity; rediocide; daphnane diterpenoid;

D O I：

10.1248/cpb.53.241

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new daphnane diterpenoid, rediocide F (1), was isolated together with three known compounds, rediocides A (2), C (3) and E (4), from the hexane extract of Trigonostemon reidioides roots by bioassay-guided fractionation for acaricidal activity on Dermatophagoides pteronyssinus, Thai common house dust mite. The structure of rediocide F (1) was established as the demethyl analog of rediocide C (3) on the basis of spectral analysis. Compounds 1-4 exhibited potent activity against D. pteronyssinus with respective LC50 values of 2.53, 0.78, 5.59 and 0.92 mug/cm(2).

引用

页码：241 / 243

页数：3

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