Interleukin-1β increases spinal cord wind-up activity in normal but not in monoarthritic rats

被引:15
作者
Constandil, L
Pelissier, T
Soto-Moyano, R
Mondaca, M
Sáez, H
Laurido, C
Muñoz, C
López, N
Hernández, A
机构
[1] Univ Santiago Chile, Neurobiol Lab, Dept Sci Biol, Fac Chem & Biol, Santiago, Chile
[2] Univ Chile, Fac Med, Program Mol & Clin Pharmacol, Inst Biomed Sci, Santiago 7, Chile
[3] Univ Chile, INTA, Santiago, Chile
关键词
interleukin-1; beta; cytokine; C-fiber reflex; wind-up; spinal cord; monoarthritis; rat;
D O I
10.1016/S0304-3940(03)00278-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cytokines produced by spinal cord glia after peripheral inflammation, infection or trauma have a relevant role in the maintenance of pain states. The effect of intrathecally administered interleukin-1beta (IL-1beta) on spinal cord nociceptive transmission was studied in normal and monoarthritic rats by assessing wind-up activity in a C-fiber-mediated reflex paradigm evoked by repetitive (1 Hz) electric stimulation. Low i.t. doses of IL-1beta (0.03. 0.12, 0.5 and 2.0 ng) dose-dependently enhanced wind-up activity in normal rats, while higher doses (8.0 ng) only produced a marginal unsignificant effect. IL-1beta administration to monoarthritic rats did not significantly change wind-up scores at any dose. Adaptive changes developed in the spinal cord during chronic pain may underlie the ineffectiveness of exogenous IL-1beta to up-regulate nociceptive transmission. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:139 / 142
页数:4
相关论文
共 20 条
[1]   Selective increases in cytokine expression in the rat brain in response to striatal injection of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1 [J].
Allan, SM ;
Harrison, DC ;
Read, S ;
Collins, B ;
Parsons, AA ;
Philpott, K ;
Rothwell, NJ .
MOLECULAR BRAIN RESEARCH, 2001, 93 (02) :180-189
[2]  
*COMM RES ETH ISS, 1980, PAIN, V9, P141
[3]   Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model [J].
DeLeo, JA ;
Colburn, RW ;
Nichols, M ;
Malhotra, A .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1996, 16 (09) :695-700
[4]   A CURE FOR WIND UP - NMDA RECEPTOR ANTAGONISTS AS POTENTIAL ANALGESICS [J].
DICKENSON, AH .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (08) :307-309
[5]   The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord [J].
Dickenson, AH ;
Chapman, V ;
Green, GM .
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1997, 28 (05) :633-638
[6]  
Ferrell B. R., 1993, Journal of Pharmaceutical Care and Pain and Symptom Management, V1, P9
[7]  
Inoue A, 1999, J NEUROCHEM, V73, P2206
[8]   Effect of ketamine on spinal cord nociceptive transmission in normal and monoarthritic rats [J].
Laurido, C ;
Pelissier, T ;
Pérez, H ;
Flores, F ;
Hernández, A .
NEUROREPORT, 2001, 12 (08) :1551-1554
[9]  
Matsukawa A, 1997, LAB INVEST, V76, P629
[10]   A METHOD TO PERFORM DIRECT TRANSCUTANEOUS INTRATHECAL INJECTION IN RATS [J].
MESTRE, C ;
PELISSIER, T ;
FIALIP, J ;
WILCOX, G ;
ESCHALIER, A .
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1994, 32 (04) :197-200