Synthesis of symmetrical amino and aminomethyl derivatives of Troger's base via Pd-catalyzed C-C and C-N bond formation

被引：31

作者：

Didier, Delphine ^{[1
]}

Sergeyev, Sergey ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Lab Chim Polymeres, B-1050 Brussels, Belgium

来源：

TETRAHEDRON | 2007年 / 63卷 / 18期

关键词：

Troger's base; cross coupling; amination; cyanation;

D O I：

10.1016/j.tet.2007.02.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, we report the synthesis of amino and aminomethyl derivatives of Troger's base (+/-)-1 and (+/-)-2. The key steps in the synthesis of (+/-)-1 and (+/-)-2 are Pd-catalyzed amination and cyanation, respectively, of the easily accessible dihalo derivatives (+/-)-3. These compounds are important intermediates in the synthesis of new ligands and building blocks for H-bonded supramolecular architectures. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3864 / 3869

页数：6

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