The regenerative effect of platelet-rich plasma on healing in large osteochondral defects

被引：259

作者：

Sun, Y. ^{[1
]}

Feng, Y. ^{[1
]}

Zhang, C. Q. ^{[1
]}

Chen, S. B. ^{[1
]}

Cheng, X. G. ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthopaed Surg, Shanghai 200233, Peoples R China

来源：

INTERNATIONAL ORTHOPAEDICS | 2010年 / 34卷 / 04期

关键词：

ARTICULAR-CARTILAGE REPAIR; IN-VIVO; BONE; CELLS;

D O I：

10.1007/s00264-009-0793-2

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Platelet-rich plasma (PRP), a platelet concentrate made of autogenous blood, has been used to improve bone and soft tissue defect healing in recent years. The aim of this study was to assess the effect of PRP on articular cartilage defects in a rabbit model. Forty-eight osteochondral defects created in the femoropatellar groove were (a) left untreated, (b) treated with autogenous PRP in a poly-lactic-glycolic acid (PLGA), or (c) with PLGA alone. Platelets were enriched 5.12-fold compared to normal blood in the PRP. After four and 12 weeks, the explanted tissue specimens were assessed by macroscopic examination, micro-computed tomography, and histological evaluation. Macroscopic examination, micro-computed tomography and histology of the newly formed cartilage and bone in the defect differ significantly between the PRP-treated and the untreated groups, and stimulatory effect of PRP on osteochondral formation was observed. In conclusion, PRP in PLGA improves osteochondral healing in a rabbit model.

引用

页码：589 / 597

页数：9

共 22 条

[1]

Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis [J].